Endocrine Abstracts

Free radicals and reactive oxygen species (ROS) participate in physiological and pathological processes in the thyroid gland. Oxidative stress caused by ROS is involved in many types of DNA damage that are associated with the initiation or the progression of numerous human cancers including thyroid tumors. One of the most mutagenic products of oxygen radical forming agents is 7,8-dihydro-8-oxoguanine (8-oxoG). The aim of the current study was to investigate expression of OGG1 ...

Introduction: Studies suggest that disturbed thyroid hormones (TH) homeostasis may lead to increased cancer risk. However, the exact role of TH in cancerogenesis is unknown. We have previously identified 15 genes linked with TH signaling in 7 cancer types and 10.967 cancer patients. Here, we investigated the influence of hypothyroidism on the expression of these 15 genes in rat tissues/organs from which the previously identified, TH-related cancer types originate.<p class=...

Introduction: Published studies suggest links between altered actions of thyroid hormones (TH) and cancer development and progression. It is not clear, however, whether these links are specific to cancer types or whether TH can globally affect cancerogenesis. Here, we performed PanCancer analysis of TH signaling pathway.Material/methods: 79 genes linked with TH signaling pathway, including genes encoding proteins involved in TH synthesis, transport, rece...